Gluon Gun is the last weapon that Gordon Freeman gets in the Black Mesa, in chapter "Lambda Core". It uses low-enriched uranium for fire. There is no info with what it fires, but, presumably, Quark–gluon plasma.
Contraption details
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It is freezed, so unfreeze it
It starts to fire only when it sees a living creature, like in original Black Mesa
To activate gluon gun, press F on the hidden metal rod
If it started to fire non stop (or you want to fire it non stop), press F on hidden barrel in backpack
You can give it to humans witout any problems, but make a phase link between hidden barrel and head of human